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What Role Does Obesity Play in Chronic Pain?

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  Obesity and chronic pain have both become important public health issues in recent years. In recent years, research has shown increasing evidence of a link between the two. Obesity is linked to chronic discomfort, according to a study. Obesity was also discovered as a factor in persons with chronic pain having more physical impairment. Excess weight is commonly retained as fat cells, as we all know. Fat cells emit a substance that triggers inflammation in our bodies, according to current research. This molecule is typically used to defend our bodies against alien cells or germs. However, when we eat a high-calorie diet, fat cells also produce these substances, making this a concern. This implies that even when we are not under assault, our bodies are flooded with these substances. As a result, we experience inflammation and discomfort as a symptom. As we walk, run, jump, and move about, our joints work as a force absorption and distribution device. It's only natural that when ou...
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Why Is Obesity Linked to Diabetes?

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Diabetes mellitus (DM) is a long-term condition that alters carbohydrate, protein, and lipid metabolism. It is caused by a lack of insulin production as a result of either a dynamic or stamped inability of the pancreatic-Langerhans islet cells to make insulin, or by abnormalities in insulin uptake within peripheral tissue. Diabetes is divided into two types: type 1 and type 2 diabetes. Obesity is thought to be responsible for 80–85% of the risk of getting type 2 diabetes. Overeating, in particular, causes endoplasmic reticulum pressure to rise (ER). When the ER is overburdened with more nutrients than it can manage, it sends an alert signal to the cell, instructing it to reduce the insulin receptors on the cell surface. This results in insulin resistance and chronically high glucose concentrations in the blood, which is unmistakably a sign of diabetes. Three specific mechanisms have been postulated to relate obesity to insulin resistance and an increased risk of type 2 diabetes: 1...
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Is it possible to stop obesity by targeting a single gene?

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Obesity is an epidemic that may decrease life expectancy by 6-20 years and is linked to cardiovascular disease , type 2 diabetes, and cancer . Multi-organ systems participate in the regulation of whole-body digestion, and a disruption of this homeostatic balance underlies obesity, metabolic disease , and their associated comorbidities. Researchers have long explored non-shivering thermogenesis (NST) as a way to burn excess calories and treat obesity by converting them to heat instead of storing them as fat. Generally, the body operates a number of feedback mechanisms that suppress unnecessary caloric consumption. Evolutionarily speaking, these forms have helped conserve energy in times of hardship. Mammals have developed mechanisms for both storing calories and using them for functions such as thermogenesis, in response to pressures of limited nourishment resources and environmental exposure. Despite gorging on high-fat foods for prolonged periods, mice whose RCAN1 gene had been remove...
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